Ears Nose and Throat

Regenerative Medicine treatment for TMJ pain and disorders

Temporomandibular joint disorders (TMD) are very common. An epidemiological study of TMD revealed that 60–70% of adults experience symptoms relating to TMD. Overall, the diagnosis and treatment of TMD costs four billion dollars per year in the United States, affecting an estimated 20 million adults in 2006, according to the NIH. Gender is the most prominent risk factor for TMD with symptoms occurring four times (4x) as often in females as compared to males. Patients with TMD present to the doctor with Jaw pain and jaw noises, Grinding of teeth, Headaches, Jaw tenderness. They are often unable to fully open mouth.

Differential Diagnosis: (what else can it be) includes: Bad tooth, Severe anxiety, Sleep apnea, Osteoarthritis in general.

Conservative Treatment: Conservative Treatment options include mouth brace, exercise consisting of stretching and manual movement of the TMJ may improve maximal mouth opening and reduce pain. If that does not work, then symptomatic relief with pharmacological agents such as NSAIDs, muscle relaxers, corticosteroids, and antidepressants to reduce TMD pain. Injection Treatments: Steroid injections or Hyaluronic acid (HA). HA is only temporary and not as good as PRP. Some research shows that PRP injections are better than Injection of with or without Arthrocentesis with or without PRP. The latest, and experimental treatment options that we offer at Phenicell Regenerative Institute are Stem cells or exosome injection. Stem Cells can be from your own body if you are 55 years old or younger. Or you can opt for potent umbilical cord mesenchymal cells from other woman to be direct injection into the TM joint. Another reasonable experimental option is Exosomes directly injected into the TM joint. Exosomes are nanoparticles of genetic material that come from stem cells. Contact our office for more information.

References:
1.) Zotti F, Albanese M, Rodella LF, Nocini PF. Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review. Int J Mol Sci. 2019 Jan 11;20(2):277.
2.) Li F, Wu C, Sun H, Zhou Q. Effect of Platelet-Rich Plasma Injections on Pain Reduction in Patients with Temporomandibular Joint Osteoarthrosis: A Meta-Analysis of Randomized Controlled Trials. J Oral Facial Pain Headache. 2020 Spring;34(2):149-156.
3.) Acri TM, Shin K, Seol D, Laird NZ, Song I, Geary SM, Chakka JL, Martin JA, Salem AK. Tissue Engineering for the Temporomandibular Joint. Adv Healthc Mater. 2019 Jan;8(2):e1801236.