Extracellular vesicles as New Type of Regenerative Medicine

Exosome

Extracellular vesicles are vesicular bodies with a bilayer membrane which are released from the cell membrane of cells in order to communicate with other cells in the body (intercellular communication). These vesicular bodies are small packets of bioactive substances including proteins, lipids, microRNA, RNA and DNA. Extracellular vesicles can be derived from mesenchymal stem cells but they can be released by many different types of cells. Extracellular vesicles play a role in CNS diseases such as stroke, Alzheimer’s Disease, Parkinson’s disease, ALS and Huntington’s disease.

Extracellular vesicles in the nervous system have a variety of functions, which includes maintaning the myelin sheath, promoting nerve axon regeneration, facilitating neuronal firing and eliminating waste. Furthermore, being so exceedingly small extracellular vesicles have the distinct advantage of being able to penetrate the blood brain barrier.

There is much animal research that extracellular vesicles are helpful but much fewer studies on human patients. However, in recent times there has been an explosion of interest in extracellular vesicles in people and Phenicell Regenerative Institute is interested in conducting some clinical trials using extracellular vesicles for various neurological and musculoskeletal diseases. Extracellular vesicles are also being studied at Massachusetts General Hospital at Harvard and Yale and result getting published in highly respected journals such as New England Journal of Medicine, Stroke and Journal of Neurosurgery. Please contact Phenicell Regenerative Institute if you are interested in learning more about exosome treatments.

Watch Neurosurgeon Joseph Shehadi MD give an overview of Extracellular vesicles . The history, the uses, and everything else you need to know about this nanoscience.


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